Diffusion tensor imaging dti studies are increasingly popular among clinicians and researchers as they provide unique insights into brain network connectivity. This research was supported by the intramural research programs of the. Diffusion tensor imaging dti is a powerful tool for investigating brain anatomical connectivity. Autism spectrum disorder asd refers to a range of conditions. However, imaging studies have suggested that alterations in axon targeting are a key feature of autism.
The value of diffusion tensor imaging for differentiating autism. Fractional anisotropy, the most widely reported dti index in ndds 2, 4, 9, 10, provides a measure of directionally dependent water molecule diffusion that correlates with coherence and integrity of. A diffusion tensor imaging study in children with adhd. To evaluate the ability of diffusion tensor imaging dti parameters for. The arc and the brain mapping unit are the cambridge node of a multicentre study of neuroanatomy and brain function in autism, called the eu aims autism interventions multicentre study. Structural mri and diffusion tensor imaging dti in asperger sydrome. A study by the collaborative program of excellence in autism. Diffusion tensor imaging in autism spectrum disorder youtube. In this study, diffusion tensor imaging dti was performed on subject groups with highfunctioning autism and controls matched for age, handedness, iq, and head size. Theories of brain abnormality in autism spectrum disorder asd have. Diffusion tensor imaging of the corpus callosum in autism. Diffusion tensor imaging of frontal lobe in autism.
Diffusion tensor imaging dti is a relatively novel neuroimaging technique that helps probe the diffusion of water in the. Diffusion tensor imaging of frontal lobe in autism spectrum disorder article pdf available in cerebral cortex 1811. In this study, diffusion tensor imaging dti was used. Asd autism spectrum disorder, 3d mprage 3dimensional magnetizationprepared rapid acquisition gradientecho, afl average fiber length, dld developmental language disorder, dti diffusion tensor imaging, fa fractional anisotropy, nv number of voxels, t2wi t2weighted imaging, tv tract volume. The most important lesson from 83,000 brain scans daniel amen tedxorangecoast duration. Since the first dti study in autism spectrum disorders asd. Distinct and nondistinct white matter disruption and dimensional brainbehavior relationships. Diffusion tensor imaging provides evidence of possible axonal. Conductivity tensor imaging cti utilizes b1 mapping and multib diffusion weighted mri to produce lowfrequency anisotropic conductivity tensor. Diffusion tensor imaging of frontal lobe in autism spectrum disorder. Distinct and nondistinct white matter disruption and dimensional brainbehavior. Dtmreit produces anisotropic conductivity tensor images by incorporating diffusion weighted mri into mreit.
The aim of our study was to compare brain connectivity among children with autism spectrum disorders asd, developmental dysphasia dd, and healthy controls. Structural mri and diffusion tensor imaging autism. The value of diffusion tensor imaging for differentiating. Software toolbox for lowfrequency conductivity and. A diffusion tensor imaging study in children with adhd, autism. Autism, diffusion tensor imaging, mri, white matter. The corpus callosum is the largest commissural white matter pathway that connects the hemispheres of the human brain. Pdf diffusion tensor imaging of frontal lobe in autism. Probing the brain in autism using fmri and diffusion tensor imaging. Diffusion tensor imaging in young children with autism. Here, we used diffusion tensor imaging dti and tract based spatial. Impaired structural connectivity of socioemotional circuits in. Diffusion tensor imaging, neuroimaging, autism, white.
Diffusion tensor imaging dti can provide additional information about the. Software toolbox for lowfrequency conductivity and current density imaging using mri. For example, diffusion tensor imaging has revealed alterations in the inferior longitudinal. Pdf probing the brain in autism using fmri and diffusion. Following removal of nonbrain tissue, the diffusion tensor was fitted at each voxel using fsl diffusion toolbox software, producing diffusion maps for. Diffusion tensor imaging in autism spectrum disorder. Diffusion tensor imaging and autism information from the.